| 甲基黄酮醇胺盐酸盐对家兔回肠收缩的影响 |
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| 引用本文： | 龙平,阎超华.甲基黄酮醇胺盐酸盐对家兔回肠收缩的影响[J].中国药理学报,1992,13(1):63-65. |
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| 作者姓名： | 龙平 阎超华 |
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| 摘 要： |
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| 关 键 词： | 兔 黄酮类 甲基黄酮醇胺 回肠 |
Effects of methylflavonolamine hydrochloride on contractility of isolated rabbit ileum] |
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| P Long,C H Yan,M S Zhang,E F Zhou.Effects of methylflavonolamine hydrochloride on contractility of isolated rabbit ileum][J].Acta Pharmacologica Sinica,1992,13(1):63-65. |
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| Authors: | P Long C H Yan M S Zhang E F Zhou |
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| Institution: | Department of Pharmacology, Shanxi Medical College, Taiyuan, China. |
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| Abstract: | Methylflavonolamine hydrochloride (MFA), verapamil (Ver), and trifluoperazine (Tri) inhibited the contractions induced by submaximal concentrations of acetylcholine (ACh) and serotonin (5-HT). IC50 values (mumol.L-1) were 33.2 +/- 0.7, 0.276 +/- 0.018, 3.83 +/- 0.23, and 15.31 +/- 0.10, 0.233 +/- 0.017, 2.33 +/- 0.20, respectively. MFA, Ver, and Tri inhibited the contractions induced by CaCl2 and pD'2 values were 4.3 +/- 0.3, 6.23 +/- 0.22, 4.99 +/- 0.24, respectively. MFA 3 mumol.L-1, Ver 0.03 mumol.L-1, and Tri 3 mumol.L-1 inhibited the contractions induced by ACh in Ca(2+)-free medium, while MFA 60 mumol.L-1, Tri 30 mumol.L-1, but not Ver 0.6 mumol.L-1, had pronounced inhibitions on extracellular calcium-dependent contractions induced by ACh. These results suggest that MFA has a calcium antagonistic effect and that MFA is similar to Tri, but not Ver, in mechanism. |
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