| 脑内注射哌仑西平对清醒兔脑电描记和惊厥的影响 |
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| 引用本文： | 蒋袁絮,彭建中.脑内注射哌仑西平对清醒兔脑电描记和惊厥的影响[J].中国药理学报,1992,13(4):319-322. |
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| 作者姓名： | 蒋袁絮 彭建中 |
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| 摘 要： |
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| 关 键 词： | 哌仑西平 密胆碱 脑电描记术 惊厥 |
Effect of intracerebral injection of pirenzepine on electroencephalography and convulsions in conscious rabbits. |
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| Y X Jiang,J Z Peng.Effect of intracerebral injection of pirenzepine on electroencephalography and convulsions in conscious rabbits.[J].Acta Pharmacologica Sinica,1992,13(4):319-322. |
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| Authors: | Y X Jiang J Z Peng |
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| Institution: | Department of Pharmacology, Ningxia Medical College, Yinchuan, China. |
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| Abstract: | Intracerebroventricular (icv) injection of pirenzepine (Pir) 2 mg.kg-1 caused EEG spike discharges, which first appeared in amygdala or hippocampus and then in midbrain reticular formation and cortex. After that rabbits developed clonic convulsions. Injection (300 micrograms) into amygdala or hippocampus also produced EEG spike discharges Hemicholinium 3 (HC-3) 50-150 micrograms.kg-1 icv inhibited the EEG spike and seizure discharges in varying degrees produced by Pir. It is suggested that Pir has a central stimulatory action which is related to cholinergic mechanism. |
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