| 5—氨基水杨酸甲酯盐酸盐和柳氮磺吡啶致畸研究 |
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| 引用本文： | 熊建民,陈植和.5—氨基水杨酸甲酯盐酸盐和柳氮磺吡啶致畸研究[J].中国药理学报,1992,13(3):265-267. |
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| 作者姓名： | 熊建民 陈植和 |
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| 摘 要： |
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| 关 键 词： | 氨基水杨酸类 吡啶 致畸 |
Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine] |
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| J M Xiong,B Liang,Y Q Mo,Z H Chen.Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine][J].Acta Pharmacologica Sinica,1992,13(3):265-267. |
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| Authors: | J M Xiong B Liang Y Q Mo Z H Chen |
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| Institution: | Institute of Materia Medica, Kunming Pharmaceutical Factory, China. |
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| Abstract: | Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differentiation, external appearance, visceral, and skeletal development were observed. In rats ig M-5-AS 56 and 556 mg.kg-1.d-1 produced no noticeable effects on the organogenesis or teratogenesis either. In mice and rats ig salicylazopyridine 410 and 1089 mg.kg-1.d-1 respectively no obvious teratogenicity was detected. However, aspirin 250 mg.kg-1.d-1 ig did bring about significant teratogenicity in rats. |
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