| 吲哚美辛缓释胶囊与普通胶囊稳态血浓度波动指数及... |
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| 引用本文： | 王锦平 刘骁. 吲哚美辛缓释胶囊与普通胶囊稳态血浓度波动指数及...[J]. 中国药理学报, 1992, 13(4): 298-301 |
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| 作者姓名： | 王锦平 刘骁 |
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| 摘 要： |
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| 关 键 词： | 吲哚美辛 生物利用度 迟效制剂 |
Serum concentration fluctuation and bioavailability comparison between indomethacin sustained-release and conventional capsules during steady state. |
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| J P Wang,L Liu,X Liu,X Y Yang,D Li,G Q Ge,Q W Huang. Serum concentration fluctuation and bioavailability comparison between indomethacin sustained-release and conventional capsules during steady state.[J]. Acta Pharmacologica Sinica, 1992, 13(4): 298-301 |
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| Authors: | J P Wang L Liu X Liu X Y Yang D Li G Q Ge Q W Huang |
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| Affiliation: | Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China. |
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| Abstract: | The comparison between indomethacin conventional capsule (CC) po 25 mg q 8 h or 25 mg tid and indomethacin sustained-release capsule (SRC) po 25 mg bid in human by crossover design showed that both maximal serum concentration (Cmax) and fluctuation index (FI%) of SRC were significantly lower than those of CC during steady state (P < 0.01). No practical differences were observed between the 2 preparations in the trough serum concentration (Cmin) and area under serum concentration-time profiles (AUC0-tau) (P > 0.05). The time period reaching maximal serum concentration (Tmax) of SRC was much more delayed than that of CC (P < 0.01). It suggested that SRC possesses a better controlled release property and could avoid a higher serum peak concentration of CC. |
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