| 苯环利定对兔急性脑缺血再灌注损伤的神经保护作用 |
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| 引用本文： | 陆亦风 邢晔忠. 苯环利定对兔急性脑缺血再灌注损伤的神经保护作用[J]. 中国药理学报, 1992, 13(3): 218-222 |
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| 作者姓名： | 陆亦风 邢晔忠 |
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| 摘 要： |
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| 关 键 词： | 苯环利定 脑缺血 脑损伤 |
Neuroprotective effects of phencyclidine on acute cerebral ischemia and reperfusion injury of rabbits. |
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| Y F Lu,Y Z Xing,B S Pan,K Y Li,F Y Sun,A Z Zhang. Neuroprotective effects of phencyclidine on acute cerebral ischemia and reperfusion injury of rabbits.[J]. Acta Pharmacologica Sinica, 1992, 13(3): 218-222 |
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| Authors: | Y F Lu Y Z Xing B S Pan K Y Li F Y Sun A Z Zhang |
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| Affiliation: | Department of Neurobiology, Shanghai Medical University, China. |
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| Abstract: | Acute cerebral ischemia and reperfusion injury of rabbits was produced by permanently occluding the vertebral arteries and temporarily clamping the common carotid arteries for 30 min. Phencyclidine [1-(phenylcyclohexyl)piperidine, PCP] 40-80 micrograms.kg-1 icv 30 min before ischemia significantly attenuated the decrease of the total power of electroencephalogram (EEG) within 30 min of ischemia and improved the recovery of brain electric activity following reperfusion. PCP 20-80 micrograms.kg-1 dose-dependently suppressed the creatine kinase (CK) release during cerebral ischemia and reperfusion, and PCP 40-80 micrograms.kg-1 reduced brain ischemic damage. These improvements indicated that PCP has protective effects on acute cerebral ischemia and reperfusion injury. |
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