| 霍乱弧菌可溶性血凝素免疫保护作用的初步探讨 |
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| 引用本文： | 宋兰珍 佘雪轩. 霍乱弧菌可溶性血凝素免疫保护作用的初步探讨[J]. 南京医科大学学报(自然科学版), 1994, 14(3): 307-309 |
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| 作者姓名： | 宋兰珍 佘雪轩 |
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| 作者单位： | 南京医科大学生物化学教研室，南京医科大学生物化学教研室，南京医科大学微生物学教研室，南京医科大学微生物学教研室 南京 210029，南京 210029，南京 210029，南京 210029 |
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| 基金项目： | 国家自然科学基金，江苏省科委社会发展项目 |
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| 摘 要： | 用本室分离纯化的霍乱弧菌可溶性血凝素及吸附霍乱菌苗免疫小鼠,用Wg_2(E1-Tor生物型)弧菌灌胃攻击,运用霍乱弧菌小鼠小肠粘附免疫抑制试验对可溶性血凝素的免疫保护作用进行了初步探讨。结果表明,可溶性血凝素对霍乱弧菌粘附小鼠肠粘膜细胞具有一定的抑制作用。
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| 关 键 词： | 霍乱弧菌 可溶性血凝素 免疫 |
A Preliminary Survey on the Protective Effect of Soluble Hemagglutinin Against Cholera in Mice |
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| Song Lanzhen,Lin Houyi. A Preliminary Survey on the Protective Effect of Soluble Hemagglutinin Against Cholera in Mice[J]. Acta Universitatis Medicinalis Nanjing, 1994, 14(3): 307-309 |
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| Authors: | Song Lanzhen Lin Houyi |
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| Affiliation: | Song Lanzhen,Lin Houyi Department of Biochemistry,Nanjing Medical University,Nanjing 210029,P. R. ChinaChen Shenbao,Ding Ruling Department of Microbiology,Nanjing Medical University,Nanjing 210029,P. R. China |
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| Abstract: | Soluble Hemagglutinin (SHA) of V. Cholerae purified in this laboratory and V. Cholerae-adsorbed on aluminium hydroxide (1.5mg/ml) were used to immune mice. Then, the mice thus immunized were attacked with Wg2(EL-Tor Biotype) by intragastric administration. The protective effect conferred by SHA to the mice was evaluated with murine intestinal adherence immune inhibition test. The results reveal that SHA plays a role in the inhibition of adherence of EL-Tor Biotype V. Cholerae to the intestinal mucos-al cells of the mice. |
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| Keywords: | Soluble Hemagglutinin(SHA) V. Cholerae Intestinal adherence immune inhibition test |
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