碳酸化羟基磷灰石水泥修复骨缺损的实验研究

目的通过动物实验观察一种新型的骨修复材料———碳酸化羟基磷灰石水泥修复骨缺损的效果。方法在10只杂种犬肱骨近端制作骨缺损动物模型,采用碳酸化羟基磷灰石水泥修复骨缺损,并以高温烧结羟基磷灰石陶瓷作为对照,分别于术后5天、4周、8周、12周和16周处死动物,通过X线和组织学观察其修复效果。结果碳酸化羟基磷灰石水泥完全充填骨缺损,界面与骨结合紧密,生物相容性良好,并且随着植入时间的延长可逐渐降解并被新生骨爬行替代,与骨整合为一体。而羟基磷灰石陶瓷不能紧密充填骨缺损,在实验期间与骨界面清晰,并且没有见到降解现象。结论碳酸化羟基磷灰石水泥具有原位固化性能,是一种较为理想的新型骨缺损修复材料。

The Experimental Study on Skeletal Repair with Carbonated Hydroxyapatite Cement

Objective To study the effect of a novel biomaterial, carbonated hydroxyapatite cement (CHC)for repairing bone defect through aminal experiment. Methods The CHC was implanted into 10 mongrels' model of proximal humeral bone defects as experimental group,whereas the sinter hydroxyapatite(HA) was implanted into the contralateral proximal humeral bone defects as control group. The animals were sacrificed at 5 days,4,8,12 and 16 weeks respectively after surgery. The specimens were studied by X-ray and histological observation. Results The bone defect was completely filled by CHC,and the interface between bone and CHC was tightly combined with good biocompatibility. The CHC would gradually degrade as the implant time prolonged and it would be substituted by new born bone, and integrated with surrounding bone. But the sintered HA couldn't tightly fill the bone defect. Its degrading was not found and the interface between bone and HA was distinctly during the experiment. Conclusion It demonstrates that the CHC processes the character of immobilization in situ. Thus it is an ideal repairing material for bone defect.