| 实验性激活黑质对大鼠癫痫发作时脑电图的影响 |
| |
| 引用本文： | 韩丹,张桂林,黎旭文,刘维泽.实验性激活黑质对大鼠癫痫发作时脑电图的影响[J].武汉大学学报(医学版),1995(4). |
| |
| 作者姓名： | 韩丹 张桂林 黎旭文 刘维泽 |
| |
| 作者单位： | 广州医学院附二医院 |
| |
| 摘 要： | 为探讨黑质抗癫痫作用的神经化学机制，实验用大鼠４０只，１２０万Ｕ青霉素（ｉｐ）诱发其癫痫（ＥＥＧ）发作．高波幅尖波连续发放型癫痫放电稳定时：（１）电刺激黑质（１０Ｈｚ、６Ｖ、０．２ｍｓ）即刻出现癫痫放电频率下降（Ｐ＜０．０５），连续刺激２５ｍｉｎ，效应最明显时停止电刺激，癫痫放电频率随即恢复，（２）黑质内微量注射多巴胺（ＤＡ）受体激动剂盐酸阿朴吗啡５μｇ，出现癫痫放电频率抑制现象（Ｐ＜０．０５），持续６０ｍｉｎ以上，部分动作癫痫放电消失后不再复现．（３）黑质内微量注射γ氨基丁酸（ＧＡＢＡ）４～５μｇ，明显易化大鼠癫痫放电频率（Ｐ＜０．０１），４０ｍｉｎ后癫痫放电频率大约是用药前的５倍，该效应可以被黑质内微量注射印防己毒素５μｇ阻断．结果提示：激活黑质ＤＡ系统功能活动有利于对抗青霉素致大鼠癫痫发作．
|
| 关 键 词： | 黑质，电刺激，青霉素，癫痫 阿朴吗啡，γ－氨基丁酸 |
Effect of Experimental Activation of Substantia Nigra on Penicillin-Induced Epileptic EEG in Rats |
| |
| Han Dan,Zhang Guilin,Li Xuwen,et al.Effect of Experimental Activation of Substantia Nigra on Penicillin-Induced Epileptic EEG in Rats[J].Medical Journal of Wuhan University,1995(4). |
| |
| Authors: | Han Dan Zhang Guilin Li Xuwen |
| |
| Abstract: | Experiments were performed on 40 adults wistar rats weighing 250～280g.Epileptiform discharges of cerebral cortex were induced by intraperitoneal injection of penicillin(1200000 U).The frequency of epileptiform discharges were depressed after electrical stimulation of SN(10 Hz,6V,0.2ms).The frequency of high-amplitude sharps were inhibited after microinjection of apomorphine(5 μ)into SN.The resuIts suggest that activation of dopaminergic receptors of SN is in favor of controlling epilepsy. |
| |
| Keywords: | substantic nigra electric stimulstion penicillins epilepsy apomorphing GABA |
| 本文献已被 CNKI 等数据库收录！ |
