环氧合酶-2和表皮生长因子受体的相关性及其在肿瘤中的应用 |
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引用本文: | 付彦超,张庆瑜.环氧合酶-2和表皮生长因子受体的相关性及其在肿瘤中的应用[J].国际肿瘤学杂志,2008,35(8):573-576. |
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作者姓名: | 付彦超 张庆瑜 |
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作者单位: | 天津医科大学总医院消化科,300052 |
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摘 要: | 环氧合酶-2(COX-2)和表皮生长因子受体(EGFR)在许多肿瘤细胞中过表达且呈现一定相关性.研究显示肿瘤细胞中COX-2和EGFR之间存在相互诱导活化;联合应用COX-2和EGFR抑制剂抑制肿瘤效果更好.
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关 键 词: | 受体 表皮生长因子 前列腺素内过氧化物合酶 肿瘤 |
Correlation of EGFR and COX-2 and their application in tumor |
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Abstract: | Cyclooxygenase-2(COX-2)and epidermal growth factor receptor(EGFR)over-express in many tumor cells and correlate in some degree. Studies show that COX-2 and EGFR can be activated by each other. The effect is better to combine COX-2 inhibitor with EGFR inhibitor in tumor therapy. |
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Keywords: | Receptor epidermal growth factor Prostaglandin-endoperoxide synthase Neoplasms |
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