Role of cyclin E and p53 expression in progression of early gastric cancer |
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Authors: | Li Jiaqing Shuichi Hokita Che Xiangming Shoji Natsugoe Gen Tanabe Masamichi Baba Sonshin Takao Takashi Aikou |
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Institution: | (1) First Department of Surgery, School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan, JP |
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Abstract: | Background. To elucidate the role that cyclin E overexpression plays in the progression of early gastric cancer, we examined the expression
of cyclin E and p53, as abnormal p53 expression is linked with cyclin E overexpression in exerting adverse affects on the cell cycle.
Methods. Specimens from 108 early gastric cancers were stained by an immunohistochemical method, using anti-cyclin E and anti-p53 antibodies.
Results. The positivity rate of cyclin E expression in early gastric cancer was 33% (36/108). Cyclin E-positive tumors invaded more
deeply (P < 0.05), infiltrated lymphatic vessels more frequently (P < 0.01), showed a higher incidence of differentiated cancer (P < 0.01), and more often expressed p53 (P < 0.01) than cyclin E-negative tumors. Differentiated cancers showing coexpression of cyclin E and p53 were more likely to metastasize to the lymph nodes.
Conclusions. Overexpression of cyclin E may promote the progression of early gastric cancer.
Received for publication on Apr. 27, 1998; accepted on Nov. 17, 1998 |
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Keywords: | : cyclin E p53 early gastric cancer tumor progression immunohistochemistry |
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