| 大鼠视皮层神经元突触后电流的发育变化 |
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| 引用本文： | 秦伟,阴正勤,王世君,赵妍君,范惠民. 大鼠视皮层神经元突触后电流的发育变化[J]. 中国现代医学杂志, 2003, 13(8): 9-11 |
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| 作者姓名： | 秦伟 阴正勤 王世君 赵妍君 范惠民 |
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| 作者单位： | 第三军医大学西南医院眼科,重庆,400038 |
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| 基金项目： | 国家自然科学基金资助 (No :3 9970 2 5 2 ) |
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| 摘 要： | 目的：揭示大鼠发育过程中视皮层神经元的突触后电流的发育特性。方法：对出生后7—28d龄大鼠进行脑片膜片钳全细胞记录，并根据输入阻抗的大小对神经元进行分类，以及分析其突触后电流的特性。结果：随着输入阻抗减小，视皮层神经元的突触后电流的峰值、上升时间和下降时间增大。结论：在大鼠生后早期的发育过程中，视觉经验调制视皮层神经元的突触可塑性。
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| 关 键 词： | 大鼠 视皮层 突触可塑性 发育 膜片钳技术 全细胞记录 |
Developmental Changes of Neuronal Postsynaptic Currents in Rat Visual Cortex |
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| Qin Wei,Yin Zhenqin,Wang Shijun. Developmental Changes of Neuronal Postsynaptic Currents in Rat Visual Cortex[J]. China Journal of Modern Medicine, 2003, 13(8): 9-11 |
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| Authors: | Qin Wei Yin Zhenqin Wang Shijun |
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| Affiliation: | Qin Wei,Yin Zhenqin,Wang Shijun Department of Ophthalmology,Southwest Hospital,Third Military Medical University,Chongqing 400038 |
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| Abstract: | Objective: To reveal the developmental properties of neuronal postsynaptic currents in rat visual cortex during development.Methods:Whole-cell patch clamp recording was performed in brain slices of rats at postnatal 7 to 28 days. The neurons were classified according to their input resistance, and then the etectrophysiological data were analysed.Results:With the decrement of input resistance, the peak value, rise time and decay time of postsynaptic currents of visual cortical neurons became larger.Conclusions: The neuronal synaptic plasticity of rat visual cortex are modulated by visual experience during the early postnatal development. |
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| Keywords: | Rat Visual Cortex Development Synaptic Plasticity Whole-cell Recording Patch Clamp Technique |
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