276例HIV/AIDS淋巴细胞亚群与中医证型的相关性研究

目的：探讨HIV/AIDS淋巴细胞亚群与中医证型的关系。方法：选择HIV/AIDS患者276例作为观察组,健康者11例作为对照组,进行淋巴细胞亚群（CD3＋、CD4＋、CD8＋、CD14＋、CD19＋、CD56＋T淋巴细胞亚群）检测并对HIV/AIDS患者进行中医辨证分型。结果：观察组各证型与对照组比较,除痰湿内蕴型外,其余各证型CD3＋、CD4＋T细胞水平均明显下降（P〈0.05）。观察组各证型之间比较,CD3＋T细胞水平气血亏虚兼痰湿型最低,与气血亏虚兼血瘀型、气血亏虚型比较,差异均有显著性意义（P〈0.05）;CD4＋T细胞水平痰湿内蕴型最低,与气血亏虚型、气血亏虚兼血瘀型比较,差异均有显著性意义（P〈0.05）;痰湿内蕴型CD14＋T、CD19＋T细胞水平较低,CD56＋T细胞水平较高,与其它各证型及对照组比较,差异均有显著性意义（P〈0.05）。结论：HIV/AIDS淋巴细胞亚群与中医证型有一定的关系,可为进一步研究HIV/AIDS中医证型及病机演变规律提供参考。

Correlation of T Lymphocyte Subsets of HIV/AIDS Patients with Syndrome Types of Traditional Chinese Medicine:A Report of 276 Cases

Objective:To explore the relationship between syndrome patterns of Traditional Chinese medicine and T lymphocyte subsets in HIV/AIDS patients.Methods:The observation groups included 276 cases of HIV/AIDS patients,and 11 healthy volunteers served as the controls.The T lymphocyte subset levels of CD3+,CD4+,CD8+,CD14+,CD19+ and CD56+ were detected,and syndrome patterns were differentiated.Results:Except for phlegm-dampness accumulation syndrome,CD3+ and CD4+ T cells levels were lower in HIV/AIDS patients with other patterns than the controls(P<0.05).Of the syndrome patterns in HIV/AIDS patients,CD3+ T cell level was lower in Qi and blood deficiency complicated with phlegm-dampness accumulation than that in the syndrome of Qi and blood deficiency complicated with blood stasis and in the syndrome of Qi and blood deficiency(P<0.05).CD4+ T cell level was lower in phlegm-dampness accumulation syndrome than that in the syndrome of Qi and blood deficiency and in the syndrome of Qi and blood deficiency complicated with blood stasis(P<0.05).CD14+ and CD19+ T cells levels were lower and CD56+ T cell level was higher in phlegm-dampness accumulation syndrome than those in the controls and HIV/AIDS patients with other syndrome patterns(P<0.05).Conclusion:The syndrome patterns of HIV/AIDS patients are correlated with T lymphocyte subsets,which will provide reference for the further research the pathogenesis evolution of HIV/AIDS.