| 脑室注射Intermedin 1-53对大鼠血压和心率的调节作用 |
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| 引用本文： | 任永生,余正堂,刘青云,王明江,汪雄,朱克刚,齐永芬,唐朝枢. 脑室注射Intermedin 1-53对大鼠血压和心率的调节作用[J]. 高血压杂志, 2006, 14(3): 201-205 |
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| 作者姓名： | 任永生 余正堂 刘青云 王明江 汪雄 朱克刚 齐永芬 唐朝枢 |
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| 作者单位： | [1]郧阳医学院生理教研室 [2]东风医院老年病科,湖北十堰442000 [3]北京大学医学部生理和病理生理系,北京100083 |
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| 基金项目： | 国家重大基础研究发展规划项目(No:G2000056905)，郧阳医学院基础科技资助项目(No:2004KY010)资助。 |
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| 摘 要： | 目的探讨Intermedinl-53对正常大鼠中枢神经调节的心血管效应及其可能的机制。方法将药物微量注射入麻醉大鼠侧脑室，观察注药后45min内血压和心率的变化。结果侧脑室注射不同剂量的Intermedinl-53后可引起血压升高和心率加快，并存在剂量和时间依赖关系。中枢注射Intermedinl-53引起的升高血压的作用明显强于肾上腺髓质素，但其增加心率的作用弱于肾上腺髓质素。Interme—dinl-53升高血压和加快心率的作用，可被预先侧脑室注射肾上腺髓质素受体拮抗剂ADM22—52以及prepro—IMD抗血清阻断。结论本工作提示Intermedinl-53是调节血压和心率的一个重要的中枢活性因子。
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| 关 键 词： | Intermedinl-53 血压 心率 调节作用 脑室注射 |
Effects of Cerebral Ventricular Injection of Intermedin1-53 on Mean Arteral Pressure and Heart Rate in Conscious Rats |
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| REN Yong-sheng ,YU Zheng-tang ,LIU Qing-yun ,WANG Ming-jiang ,WANG Xiong ,ZHU Ke-gang ,,QI Yong-fen ,TANG Chao-shu .. Effects of Cerebral Ventricular Injection of Intermedin1-53 on Mean Arteral Pressure and Heart Rate in Conscious Rats[J]. Chinese Journal of Hypertension, 2006, 14(3): 201-205 |
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| Authors: | REN Yong-sheng YU Zheng-tang LIU Qing-yun WANG Ming-jiang WANG Xiong ZHU Ke-gang QI Yong-fen TANG Chao-shu . |
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| Affiliation: | REN Yong-sheng 1,YU Zheng-tang 2,LIU Qing-yun 2,WANG Ming-jiang 1,WANG Xiong 1,ZHU Ke-gang 1,2,QI Yong-fen 3,TANG Chao-shu 3. 1. Department of Physiology, 2. Dongfeng Hospital Yunyang Medical college,Shiyan,Hubei 442000, 3. Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100083, China |
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| Abstract: | Objective To determine the effects cerebral ventricular injection of the intermedin1-53 fragment on mean arterial blood pressure and heart rate in normal rats and its possible mechanism. Methods Rats were given intermedin1-53(IMD1-53) or adrenomedullin intracerebroventricularly(ICV). Blood pressure and heart rate was monitored for 45 min. Results The ICV injection of intermedin1-53 (0.1, 0.5 and 1.0 nmol/kg) resulted in a dose and time related increases in mean arterial pressure and heart rate. The effects were more prominent than that by equivalent dose of adrenomedullin. The CNS action of intermedin1-53 was blocked by ADM22-52 or prepro-IMD antibody. Conclusion These data suggest that central injection of intermedin 1-53 may regulate BP and HR. |
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| Keywords: | Intermedin1-53 Blood pressure Heart rate |
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