苦参素胶囊联合复方丹参滴丸治疗乙肝后肝纤维化的临床研究

目的:观察苦参素胶囊联合复方丹参滴丸对慢性乙肝肝纤维化的治疗效果。方法:54例慢性乙肝肝纤维化患者随机分为对照组和联合治疗组,观察治疗前、后肝功能、肝纤维化指标和HBV标志物的变化。结果:治疗后联合治疗组各项指标均较治疗前及对照组有明显改善(P<0.05或P<0.01)。结论:苦参素胶囊联合复方丹参滴丸可明显控制乙肝患者的肝脏炎症,显著提高抗肝纤维化作用,可抑制HBV复制且无严重不良反应。

Clinical evaluation on marine capsules combined with the composite Salvia miltiorrhiza dropping pill in treatment of patients with cirrhosis related to chronic hepatitis B

AIM: To investigate the therapeutic effects of the marine capsules combined with composite Salvia miltiorrhiza dropping pill in treatment with patients with hepatic fibrosis related to chronic hepatitis B. METHODS: 54 patients were enrolled and randomly divided into control group and treatment group. The liver function,the marker of hepatic fibrosis and hepatitis B virus were determined before and after therapy. RESULTS: The markers in this study were significantly improved than those before treatment and those in control group (P<(0.05) or P<(0.01)). CONCLUSION: The marine capsules combined with composite Salvia miltiorrhiza dropping pill can effectively control the activity of liver inflammation in the patients with chronic hepatitis B and markedly heighten the effects in treatment of patients with hepatic fibrosis and inhibit the replication of HBV without severe side effect.