The influence of dietary citrate on the absorption and retention of orally ingested lead |
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Authors: | J T Spickett R R Bell J Stawell S Polan |
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Institution: | (1) School of Community Health, Western Australian Institute of Technology, Kent Street, 6102 Bentley, Western Australia |
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Abstract: | The influence of dietary citrate on the toxicity of orally ingested lead was investigated in male weanling mice. Twenty-four animals were divided into three equal groups. Group 1 served as controls, groups 2 and 3 were given 20 g lead (as lead acetate) per g/diet, group 3 also received 4% sodium citrate in the diet.After 5 weeks, blood and tissue lead levels were measured. All mice given lead-supplemented diets had higher concentrations of lead in blood, liver, kidney, brain and bone than the control group, but the increase was significantly greater in the group given 4% sodium citrate in the diet. This work demonstrated that dietary citrate at levels which can be present in food significantly increases lead toxicity. |
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