Time-dependent change in the effect of probucol in subjects with elevated cholesterol |
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Authors: | A. Fujimura M. D. K. Ohashi A. Ebihara |
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Affiliation: | (1) Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun, 329-04 Tochigi, Japan |
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Abstract: | Summary A time-dependent change in the cholesterol-lowering effect of probucol has been evaluated in 20 subjects with elevated cholesterol. Probucol 500 mg was given once daily at 07.00 h (day trial) or 19.00 h (night trial) for 3 months according to a crossover design. Fasting blood samples were obtained during the control period and at the end of each treatment period. Serum concentrations of total and HDL-cholesterol were significantly decreased by both the treatments with probucol [total cholesterol (mmol · l−1): control 6.58; day trial 5.41; night trial 5.10; HDL-cholesterol (mmol · l−1): control 1.35; day trial 1.06; night trial 0.96]. These parameters were significantly lower in the night trial than in the day trial. The data indicate that the cholesterol-lowering effect of probucol varies with its time of administration in subjects with elevated cholesterol. |
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Keywords: | Probucol elevated cholesterol, chronopharmacology |
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