| 抗甲状腺药物对~(131)I治疗甲状腺功能亢进症疗效的影响 |
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| 引用本文： | 张林,安振梅. 抗甲状腺药物对~(131)I治疗甲状腺功能亢进症疗效的影响[J]. 国际内分泌代谢杂志, 2006, 0(5) |
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| 作者姓名： | 张林 安振梅 |
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| 作者单位： | 四川大学华西医院实验医学科激素检测室 610041成都 |
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| 摘 要： | 131I是治疗甲状腺功能亢进症(甲亢)的主要药物之一,治疗前应用硫氧嘧啶类药物如丙硫氧嘧啶可能会降低131I治疗甲亢的治愈率,咪唑类药物如甲巯咪唑则不会影响其疗效。131I治疗甲亢后应用丙硫氧嘧啶或甲巯咪唑对131I疗效的影响尚有争议之处。抗甲状腺药物影响131I疗效的机理可能在于改变了131I的有效半衰期和(或)甲状腺对131I的摄取率。
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| 关 键 词： | 抗甲状腺药物 放射性碘 甲状腺功能亢进症 |
Effect of antithyroid drugs on the efficacy of ~(131)I in the treatment of hyperthyroidism |
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| ZHANG Lin,AN Zhen-mei. Effect of antithyroid drugs on the efficacy of ~(131)I in the treatment of hyperthyroidism[J]. International JOurnal of Endocrinology and Metabolism, 2006, 0(5) |
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| Authors: | ZHANG Lin AN Zhen-mei |
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| Affiliation: | ZHANG Lin,AN Zhen-mei.Division ofHormone Assay,Department ofLaboratory Medicine,West China Hospital,Sichuan Universi-ty,Chengdu610041,China |
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| Abstract: | 131I plays animportant role inthe treatment of hyperthyroidism.Propylthiouracil,whichis usedbefore 131I,can reduce the efficacy of 131I.However,methimazole does not.There exits contrary ideas aboutwhether propylthiouracil and methimazole used after 131I might influence its efficacy.Antithyroid drugs may influ-ence the efficacy of 131I,the possible mechanism might be that antithyroid drugs change the effective half-time and(or) uptake of 131I. |
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| Keywords: | Antithyroid drugs 131I Hyperthyroidism |
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