利咽含片质量标准研究

目的:建立利咽含片质量标准。方法:采用薄层色谱(TLC)法对利咽含片中桔梗、甘草、麦冬、南沙参进行鉴别,采用高效液相色谱(HPLC)法测定绿原酸、黄芩苷、甘草酸的含量。结果:桔梗、甘草、麦冬、南沙参定性鉴别灵敏、专属性好;绿原酸、黄芩苷、甘草酸的进样量分别在0.945～7.560、0.1625～1.3000、0.3825～3.0640μg范围内与峰面积积分值呈良好线性关系;三者平均回收率分别为99.98%、100.53%、100.22%,RSD分别为1.8%、2.1%、2.2%。结论:所建标准可用于利咽含片的质量控制。

Quality Standards of Liyan Buccal Tablets

OBJECTIVE:To establish the quality standards for Liyan buccal tablets.METHODS:The Radix Platycodonis,Radix Et Rhizoma Glycyrrhizae,Radix Ophiopogonis and Radix Adenophorae in Liyan buccal tablets were identified by TLC,and the contents of Chlorogenic acid,Baicalin and Glycyrrhizic acid were determined by HPLC.RESUTLS:The qualitative identification of Radix Platycodonis,Radix Glycyrrhizae,Radix Ophiopogonis and Radix Adenophorae showed good sensitivity and specificity.The linear ranges of Chlorogenic acid,Baicalin and Glycyrrhizic acid were 0.945 ～ 7.560,0.162 5 ～ 1.300 0,and 0.382 5 ～ 3.064 0μ g,respectively.The average recoveries of the three were 99.98%,100.53% and 100.22%,respectively with RSD at 1.8%,2.1%,and 2.2%,respectively.CONCLUSION:The established standards can be used for the quality control of Liyan buccal tablets.