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| PI3K和caspase-3在鼻咽癌中的表达及意义 | |
| 引用本文： | 陈英杰,刘 健,陶雅君,贾心善.PI3K和caspase-3在鼻咽癌中的表达及意义[J].大连医科大学学报,2007,29(2):120-121. |
| 作者姓名： | 陈英杰 刘 健 陶雅君 贾心善 |
| 作者单位： | 1. 中国医科大学,病理学教研室,辽宁,沈阳,110001;大连大学,医学院,病理学教研室,辽宁,大连,116622 2. 大连大学,医学院,病理学教研室,辽宁,大连,116622 3. 中国医科大学,病理学教研室,辽宁,沈阳,110001 |
| 摘 要： | 目的]观察鼻咽癌（nasopharyngeal carcinoma,NPC）组织PI3K和caspase-3的表达,探讨其相互关系及其在鼻咽癌发生发展中的作用。方法]应用免疫组织化学法检测60例鼻咽癌与23例鼻咽部慢性炎症组织PI3K和caspase-3的表达水平。结果]NPC组中PI3K的阳性率分别为86.7%（52/60）与60.9%（14/23）（P〈0.05）;caspase-3的表达率分别为48.3%（29/60）与73.9%（17/23）（P〈0.05）;NPC中,PI3K的表达强度与caspase-3的表达呈负相关（P〈0.05）。结论]PI3K/Akt/mTOR信号通路的激活可能通过某种机制抑制caspase-3的表达,进而减少肿瘤细胞的凋亡,这在鼻咽癌的发病中起一定的作用。 |
| 关 键 词： | 鼻咽癌 P13K caspase-3 |
| 文章编号： | 1671-7295(2007)02-0120-02 |
| 修稿时间： | 2006年12月27 |
Expression of PI3K and caspase-3 in nasopharyngeal carcinoma |
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| CHEN Ying-jie,LIU Jian,TAO Ya-jun and JIA Xin-shan.Expression of PI3K and caspase-3 in nasopharyngeal carcinoma[J].Journal of Dalian Medical University,2007,29(2):120-121. | |
| Authors: | CHEN Ying-jie LIU Jian TAO Ya-jun and JIA Xin-shan |
| Institution: | Department of Pathology, China Medical University, Shenyang 110001, China; Department of Pathology, Medical College of Dalian University, Dalian 116622, China;Department of Pathology, Medical College of Dalian University, Dalian 116622, China;Department of Pathology, Medical College of Dalian University, Dalian 116622, China;Department of Pathology, China Medical University, Shenyang 110001, China; |
| Abstract: | Objective] To investigate the effects of expressions of PI3K and caspase-3 on the tumorigenesis in nasopharyngeal carcinoma.Methods]Immunohistochemical method was used to examine expressions of PI3K and caspase-3 in 60 nasopharyngeal carcinomas(group1) and 23 non-tumor nasopharyngeal tissues(group2).Results]In group 1 and group 2,the expression rates of PI3K were 86.7%(52/60) and 60.9%(14/23) respectively,(P<0.05);While the rates of caspase-3 were 48.3%(29/60) and 73.9%(17/23) respectively,(P<0.05).The expression of caspase-3 was negatively correlated with that of PI3K in nasopharyngeal carcinoma(P<0.05).Conclusion] The activation of PI3K/Akt/mTOR signaling pathway may inhibit the expression of caspase-3 to decrease apoptosis and promote proliferation of NPC cells. |
| Keywords: | nasopharyngeal carcinoma PI3K caspase-3 |
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