能量多普勒检测膀胱癌血流相对灌注率及其与MVD、VEGF表达的相关性

目的 探讨能量多普勒(PDI)技术检测膀胱癌肿瘤内血流相对灌注率及其与微血管密度(MVD)、血管内皮细胞生长因子(VEGF)表达的关系.方法 采用经直肠PDI技术检测45例膀胱癌患者肿瘤内血流信号,计算相对灌注率,术后采用免疫组化技术检测肿瘤MVD及VEGF表达.结果 肿瘤内血流相对灌注率与MVD、VEGF阳性表达呈正相关.MVD、VEGF表达与膀胱癌的病理分级及浸润程度相关.VEGF表达阳性者MVD高于VEGF表达阴性者.结论 能量多普勒超声联合上述免疫组化指标可从不同角度反映膀胱癌的血管生成特征,有助于对膀胱癌血管生成进行评价.

Intratumoral relative perfusion rate and the relation between MVD and expression of VEGF assessed with power Doppler imaging: in bladder carcinoma

Objective To evaluate the relationship between relative perfusion rate assessed with power Doppler imaging (PDI) and microvessel density (MVD), as well as expression of vascular endothelial growth factor (VEGF) in bladder carcinoma. Methods The transrectal ultrasound (TRUS) blood flow signal of bladder carcinoma was preoperatively detected with color Doppler imaging in 45 patients, and the relative perfusion rates were obtained for analysis. MVD and the expression of VEGF of excised tumor were assessed immunohistochemically. Results There were correlation between relative perfusion rate and MVD, the expression of VEGF. MVD and the expression of VEGF were related to pathologic grade and the invasiveness of tumor tissues. The expression of VEGF in bladder carcinoma was positively correlated to the tumor interstitial vascular density. Conclusion Combination of PDI and immunohistochemical parameters is useful for evaluating the angiogensis of bladder carcinoma from a different point of view.