The Janus face of N-terminal lysines in α-synuclein |
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作者姓名: | Ana Belén Uceda Laura Mari?o Miquel Adrover |
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作者单位: | Institut Universitari d’Investigació en Ciències de la Salut (IUNICS) |
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基金项目: | supported by the Spanish Government in the framework of Project CTQ2014-55835-R;LM thanks MINECO for award of FPU PhD Grant FPU14/01131 |
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摘 要: | Parkinson’s disease(PD)is the second most prevalent progressive neurodegenerative disorder after Alzheimer’s disease.PD usually starts with a tremor in the extremities(usually in the hands)and gradually evolves with other symptoms such as bradykinesia,muscle stiffness,impaired posture,loss of automatic movements or speech changes.These symptoms worsen as the condition progresses and eventually lead to death.
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关 键 词: | IMPAIRED ALZHEIMER eventually |
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