Hematopoietic stem cell transplantation and acute kidney injury in children: A comprehensive review |
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| Authors: | Rupesh Raina Nicholas Herrera Vinod Krishnappa Sidharth Kumar Sethi Akash Deep Wei‐Ming Kao Timothy Bunchman Rolla Abu‐Arja |
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| Affiliation: | 1. Department of Pediatric Nephrology, Akron Children's Hospital, Akron, OH, USA;2. Department of Pediatrics‐Nephrology, UH Rainbow Babies and Children's Hospital, Cleveland, OH, USA;3. Cleveland Clinic Akron General/Akron Nephrology Associates, Akron, OH, USA;4. Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, Haryana, India;5. Department of Paediatric Intensive Care, King's College Hospital, London, UK;6. Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH, USA;7. Children's Hospital of Richmond, VCU School of Medicine, Richmond, VA, USA;8. Department of Pediatric Hematology & Oncology Pediatrics, Nationwide Children's Hospital/Ohio State University, Columbus, OH, USA |
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| Abstract: | AKI in the setting of HSCT is commonly investigated among adult patients. In the same way, malignancies requiring treatment with HSCT are not limited to the adult patient population, AKI following HSCT is frequently encountered within pediatric patient populations. However, inadequate information regarding epidemiology and pathophysiology specific to pediatric patients prevents development of appropriate and successful therapeutic strategies for those afflicted. Addressing AKI in the context of sinusoidal obstruction syndrome, chemotherapy, thrombotic microangiopathy and hypertension post chemotherapy, glomerulonephritis, and graft versus host disease provides greater insight into renal impairment associated with these HSCT‐related ailments. To obtain a better understanding of AKI among pediatric patients receiving HSCT, we investigated the current literature specifically addressing these areas of concern. |
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| Keywords: | acute kidney injury bone marrow transplant hematopoietic stem cell transplantation pediatric |
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