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Toxic epidermal necrolysis in a child 6 months post‐hematopoietic stem cell transplantation |
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| Authors: | Utako Oba Hiroshi Yamada So‐ichi Suenobu Yusuke Nakamura Akiko Ito Yutaka Hatano Nobuyoshi Itonaga Kouichi Ohshima Yuhki Koga Shouichi Ohga Kenji Ihara |
| Affiliation: | 1. Department of Pediatrics, Oita University Faculty of Medicine, Oita University, Oita, Japan;2. Department of Dermatology, Oita University Faculty of Medicine, Oita University, Oita, Japan;3. Department of Pediatrics, Oita Prefectural Hospital, Oita, Japan;4. Department of Pathology, School of Medicine, Kurume University, Kurume, Japan;5. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;6. Department of Pediatrics, Graduate School of Medicine, Yamaguchi University, Ube, Japan |
| Abstract: | TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B‐cell acute lymphoblastic leukemia (pre‐B‐ALL) in second complete remission. Although we did not evaluate the T‐cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN. |
| Keywords: | EB virus infection graft‐versus‐host disease hematopoietic stem cell transplantation toxic epidermal necrolysis |