|
|||||
|
|
Dopamine as a potential rescue therapy for refractory protein‐losing enteropathy in Fontan‐palliated patients |
|
| Authors: | Joshua M. Friedland‐Little Robert J. Gajarski Kurt R. Schumacher |
| Affiliation: | 1. Division of Pediatric Cardiology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA;2. Division of Pediatric Cardiology, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA;3. Division of Pediatric Cardiology, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA |
| Abstract: | PLE is an important cause of morbidity and mortality in patients who have undergone Fontan palliation. While multiple PLE therapies have been reported, none has proved consistently effective. Patients who do not respond to “standard” PLE therapies face poor long‐term outcomes. We report here a significant response to dopamine infusion in three patients with chronic, refractory PLE. We hypothesize that this response may be at least partially due to a dopamine effect on lymphatic receptors rather than to an augmentation of cardiac output. |
| Keywords: | dopamine fontan operation heart transplantation protein‐losing enteropathy |