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Phylogenetic hierarchy of antigen-presenting ability in antigen-specific T cell activation |
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| Authors: | A Yano K Yui K Yamashita F Aosai N Okumura K Yabu |
| Affiliation: | Laboratory of Immunology, Department of Infectious Diseases and Parasitology, Shinshu University School of Medicine, Matsumoto City, Nagano 390, Japan |
| Abstract: | The phylogenetic hierarchy of antigen-presenting ability was shown to exist in xenogeneic mouse, rat and human T cell-antigen-presenting cell (APC) interaction. The antigen-presenting ability of human APC is dominant over that of rat APC and the ability of rat APC is dominant over that of mouse APC. The HLA-DR molecule was shown to function for antigen presentation to PPD-specific autologous human and xenogeneic murine T cells. |
| Keywords: | phylogenetic hierarchy antigen presenting ability T cell APC MHC major histocompatibility complex MLR mixed lymphocyte responses APC antigen-presenting cells CTL cytotoxic T cell PPD purified protein derivative PBL peripheral blood leukocytes LNL lymph node lymphocytes CFA complete Freund's adjuvant |
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