Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats |
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Authors: | Seul Min Choi Mi Jeong Seo Kyung Koo Kang Jeong Hoon Kim Byoung Ok Ahn Moohi Yoo |
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Institution: | (1) Research Center, Dong-A Pharmaceutical Company, Yongin, 446-905, Korea |
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Abstract: | A combination of antihypertensive agents can better control blood pressure and reduce the number and severity of side effects
than a monotherapy. Since both CCBs (calcium channel blockers) and ARBs (angiotensin II receptor type-1 blockers) are current
and effective antihypertensive drugs, this study assessed the synergistic antihypertensive effects as well as the optimal
combination ratio of these two drugs. Amlodipine (3 mg/kg) or losartan (30 mg/kg) alone or a combination of each drug at a
ratio 1:10 and 1:20 was administered orally to spontaneously hypertensive rats (SHR). A four-week treatment of either 3 mg/kg
amlodipine or 30 mg/kg losartan alone decreased the systolic blood pressure (SBP). However, their combination significantly
lowered the SBP from the 3rd week, and there was a positive correlation between this reduction in blood pressure and the improvement in arterial endothelium-dependent
relaxation. In addition, the combination therapy (1:20) decreased both the cardiac mass and left ventricular weight to a greater
extent than with either amlodipine or losartan alone. The collagen content in the cardiac tissue was also significantly lower
after the 4-week combination therapy (1:10). These results suggest that the combined use of amlodipine and losartan might
be more effective in treating hypertension than a monotherapy. |
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Keywords: | Amlodipine Losartan Combination Spontaneously hypertensive rat Systolic blood pressure |
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