| 血管内皮生长因子-C mRNA和微血管密度与乳腺癌预后相关性关系的探讨 |
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| 引用本文： | 陈骏,于亮,段绍斌,居来提,史志涛,孙振柱.血管内皮生长因子-C mRNA和微血管密度与乳腺癌预后相关性关系的探讨[J].中华肿瘤防治杂志,2009,16(24):1928-1931. |
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| 作者姓名： | 陈骏 于亮 段绍斌 居来提 史志涛 孙振柱 |
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| 作者单位： | 1. 新疆医科大学附属中医医院普外一科,新疆,乌鲁木齐,832000
2. 乌鲁木齐市自治区人民医院病理科,新疆,乌鲁木齐,832001 |
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| 摘 要： | 目的:探讨乳腺癌组织内血管内皮生长因子-C mRNA(VEGF-C mRNA)的表达及微血管密度(MVD),分析MVD和VEGF-CmRNA表达与乳腺癌患者预后的意义.方法:采用原位杂交技术观察92例乳腺浸润性导管癌(IDC)组织中VEGF-C mRNA的表达;CD105(细胞膜糖蛋白)标记乳腺癌组织中微血管并观察MVD.结果:不同组织学分级乳腺IDC组织中VEGF-C mRNA表达差异有统计学意义,P<0.05;在淋巴结转移组VEGF-CmRNA表达明显高于淋巴结未转移组,P<0.01;VEGF-C mRNA表达阳性组MVD明显高于VEGF-C mRNA表达阴性组,P<0.001;淋巴结转移组乳腺癌组织中MVD高于淋巴结未转移组,差异有统计学意义(P<0.001),VEGF-C mRNA表达阳性组(高MVD组)较VEGF-C mRNA表达阴性组(低MVD组)5年生存率低,差异有统计学意义,P<0.05.结论:VEGF-C mRNA表达与乳腺癌淋巴结转移及MVD密切相关,检测乳腺癌组织中VEGF-C mRNA表达及观察MVD可能预测乳腺癌预后.
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| 关 键 词： | 乳腺肿瘤 血管内皮生长因子C 信使 微血管密度 预后 |
Relationship between vascular endothelial growth factor-C mRNA and microvessel density and prognosis in breast cancer |
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| CHEN Jun,YU Liang,DUAN Shao-bin,JU Lai-ti,SHI Zhi-tao,SUN Zhen-zhu.Relationship between vascular endothelial growth factor-C mRNA and microvessel density and prognosis in breast cancer[J].Chinese Journal of Cancer Prevention and Treatment,2009,16(24):1928-1931. |
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| Authors: | CHEN Jun YU Liang DUAN Shao-bin JU Lai-ti SHI Zhi-tao SUN Zhen-zhu |
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| Institution: | CHEN Jun1,YU Liang1,DUAN Shao-bin1,JU Lai-ti1,SHI Zhi-tao,SUN Zhen-zhu21.Department of General Surgery,Traditional Chinese Medicine Hospital,Xinjiang Medical University,Urumqi 832000,P.R.China2.Department of Pathology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 832001,P.R.China |
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| Abstract: | OBJECTIVE:To study the significance of expression of vascular endothelial growth factor-C(VEGF-C mRNA) and microvessel density(MVD) in invasive breast cancer,and investigate the relationship between VEGF-C mRNA and MVD and the prognosis in breast cancer patients. METHODS:In situ hybridization was used to detect the expression of VEGF-C mRNA. CD105 was used to detect MVD in breast cancer. RESULTS:With increasing of the pathological grade,the VEGF-C mRNA expression was high (P<0.05). The VEGF-C mRNA expressio... |
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| Keywords: | RNA |
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