| 卡铂碳铁纳米球对大鼠移植性肝癌的靶向性研究 |
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| 引用本文： | 郭跃华,严文辉,桂玲,庞学斌,李富荣,鲍世韵,周汉新.卡铂碳铁纳米球对大鼠移植性肝癌的靶向性研究[J].中华肿瘤防治杂志,2009,16(23):1828-1831. |
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| 作者姓名： | 郭跃华 严文辉 桂玲 庞学斌 李富荣 鲍世韵 周汉新 |
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| 作者单位： | 1. 暨南大学第二临床医学院深圳市人民医院肝胆胰外科,广东,深圳,518020
2. 华中科技大学同济医学院附属同济医院药学部,湖北,武汉,430030 |
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| 基金项目： | 深圳市科技计划重点项目，广东省自然科学基金，广东省名医工程研究项目，深圳市科技计划项目 |
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| 摘 要： | 目的:观察卡铂碳铁纳米球(C-C&Fe-N)经肝动脉注射,结合体外磁场引导下,在移植性肝癌大鼠体内的靶向分布情况.方法:移植性肝癌大鼠40只为A组,健康大鼠40只为B组.肝动脉插管,注入C-C&Fe-N,以肿瘤(A组)或肝左叶(B组)为靶区,施加磁场30 min(5 000 Gs).分别于相应时间点,采集肿瘤或靶区肝、非靶区肝、肾、脾、肺和心组织标本,测定卡铂浓度,显微镜观察C-C&Fe-N在各脏器沉积情况.结果:A组靶区肿瘤组织卡铂峰浓度(Cmax)65.21μg/g,为B组靶区肝组织38.47 μg/g的1.7倍,为A组非靶区肝组织14.36 μg/g的4.5倍.48 h时A组靶区肿瘤组织卡铂浓度7.27 μg/g,为B组靶区肝组织3.11μg/g的2.3倍,为A组非靶区肝组织0.32 μg/g的22.7倍.各时间点,A组肿瘤组织药物浓度均成倍高于B组靶区肝组织和两组非靶区肝组织,差异有统计学意义,P<0.05.A组靶区肿瘤组织卡铂AUC是906(μg·h)/g,为B组靶区肝组织421.34(μg·h)/g的2.2倍,为A组非靶区肝组织86.47(μg·h)/g的10.5倍.结论:C-C& Fe-N在体内显示出良好的磁靶向性和药物缓释性,并且对肿瘤组织具有更强的靶向性,能成倍提高肿瘤组织中的药物浓度,延长维持时间.
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| 关 键 词： | 磁靶向 纳米球 卡铂 肝肿瘤 大鼠 |
Targeted biodistribution of carboplatin-C Fe nanocage-loaded chitosan nanoparticles in rats with transplanted liver cancer |
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| GUO Yue-hua,YAN Wen-hui,GUI Ling,PANG Xue-bin,LI Fu-rong,BAO Shi-yun,ZHOU Han-xin.Targeted biodistribution of carboplatin-C Fe nanocage-loaded chitosan nanoparticles in rats with transplanted liver cancer[J].Chinese Journal of Cancer Prevention and Treatment,2009,16(23):1828-1831. |
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| Authors: | GUO Yue-hua YAN Wen-hui GUI Ling PANG Xue-bin LI Fu-rong BAO Shi-yun ZHOU Han-xin |
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| Institution: | GUO Yue-hua1,YAN Wen-hui1,GUI Ling2,PANG Xue-bin1,LI Fu-rong1,BAO Shi-yun1,ZHOU Han-xin11.Department of Hepatobiliary Surgery,Shenzhen People's Hospital,Second Clinical Medicine College of Jinan University,Shenzhen 518020,P.R.China2.Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China |
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| Abstract: | OBJECTIVE:To observe the targeted biodistribution of Carboplatin-C & Fe Nanocage-loaded Chitosan Nanoparticles (C-C & Fe-N) injected by hepatic artery under magnetic field in rats with transplanted liver cancer.METHODS:Forty rats with transplanted liver cancer were composed of Group A.Forty normal rats were composed of Group B.Abdominal exposure was carried out through a midline incision,and a cannula was inserted into the hepatic artery and fixed.C-C & Fe-N was injected into hepatic artery.The tumors (Grou... |
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| Keywords: | magnetic target nanoparticles carboplatin liver neoplasms rats |
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