| 宫颈鳞状上皮病变组织中乳头状瘤病毒和Ki-67及p16INK4a蛋白表达意义的研究 |
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| 引用本文： | 陈海霞,刘爱云,时念学,黄卫华,张彪.宫颈鳞状上皮病变组织中乳头状瘤病毒和Ki-67及p16INK4a蛋白表达意义的研究[J].中华肿瘤防治杂志,2009,16(22):1786-1788. |
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| 作者姓名： | 陈海霞 刘爱云 时念学 黄卫华 张彪 |
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| 作者单位： | 单县中心医院病理科,山东,单县,274300 |
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| 摘 要： | 目的:探讨Ki-67、p16INK4a和人乳头状瘤病毒(HPV)在不同程度宫颈鳞状上皮病变组织中的表达及临床病理意义.方法: 采用原位分子杂交及免疫组化方法,检测HPV的不同亚型、Ki-67、p16INK4a蛋白在182例不同程度宫颈病变组织中的表达.结果: HPV在不同程度病变中总检出率52.19%(95/182);在宫颈高级别上皮内瘤变及鳞癌组中检出最多的感染类型为HPV16/18,而HPV6/11在尖锐湿疣组检出率87.50%(21/24)最高;随着宫颈病变严重程度的增加,级别升高,Ki-67、p16INK4a阳性程度呈递增趋势.Ki-67、p16INK4a与HPV16/18型感染关系密切,χ2=11.779 8, P<0.01;Ki-67也与HPV6/11型有关.结论: HPV16/18型及Ki-67、p16INK4a 在宫颈高级别上皮内瘤变及鳞癌中表达明显升高,可能对宫颈鳞癌的发生、发展具有协同作用.
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| 关 键 词： | 癌 鳞状细胞 宫颈肿瘤 乳头状瘤病毒科 核蛋白质类 免疫组织化学 |
Expressions of Ki-67 p16INK4a and HPV in squamous cell lesions of cervix tissues |
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| CHEN Hai-xia,LIU Ai-yun,SHI Nian-xue,HUANG Wei-hua,ZHANG Biao.Expressions of Ki-67 p16INK4a and HPV in squamous cell lesions of cervix tissues[J].Chinese Journal of Cancer Prevention and Treatment,2009,16(22):1786-1788. |
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| Authors: | CHEN Hai-xia LIU Ai-yun SHI Nian-xue HUANG Wei-hua ZHANG Biao |
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| Institution: | CHEN Hai-xia,LIU Ai-yun,SHI Nian-xue,HUANG Wei-hua,ZHANG BiaoDepartment of Pathology,Shanxian Central Hospital,Shanxian 274300,P.R.China |
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| Abstract: | OBJECTIVE: To explore the clinicopathologic significance of the Ki-67,p16INK4a and humen papilloma virus(HPV) expressions in the diseased cervical tissues with different degrees of severity.METHODS: Situ hybridisation and immunonhistochemistry were used to detect the expressions of the different subtypes of HPV,Ki-67 and p16INK4a in 182 cases of the diseased cervix tissues with diffrent degrees of severity.RESULTS: The positive rate of HPV in all specimens was 52.19%(95/182).HPV16/18 was mostly detected in ... |
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| Keywords: | carcinoma squamous cell cervix neoplasms papillomaviridae nuclear proteins immunohistochemistry |
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