急性心肌梗死患者血清血管内皮生长因子与一氧化氮检测的意义

目的:检测急性心肌梗死患者血清血管内皮生长因子和一氧化氮水平,探讨血管内皮生长因子和一氧化氮在急性心肌梗死发病中的作用。方法:选择冠心病患者60例,其中稳定型心绞痛30例,急性心肌梗死30例,健康人30例为对照组,均于入院第1 d抽取空腹静脉血测定血清血管内皮生长因子及一氧化氮的水平。结果:冠心病患者血清中血管内皮生长因子含量明显高于正常对照组(P<0.01);急性心肌梗死组血清中血管内皮生长因子含量明显高于稳定型心绞痛组和正常对照组(P<0.01);冠心病患者血清中一氧化氮含量低于正常对照组(P<0.01),急性心肌梗死患者血清中血管内皮生长因子含量低于稳定型心绞痛组和正常对照组(P<0.01)。结论:冠心病患者血清中血管内皮生长因子含量高而一氧化氮含量低,提示动脉发生粥样硬化的过程中,血管内皮生长因子与一氧化氮相互调节的作用可能发生障碍,血管内皮生长因子与一氧化氮调节失衡可能与动脉粥样硬化发生、发展有关。

Changes of serum vascular endothelial growth factor and nitric oxide in patients with acute myocardial infarction

Objective To investigate the changes of serum vascular endothelial growth factor and nitric oxide in the patients with acute myocardial infarction and their significance.Methods Sixty patients with coronary heart disease were divided into group A(30 patients with stable angina pectoris) and group B(30 patients with acute myocardial infarction).Another 30 healthy middle-aged people were enrolled in group C.Blood samples were taken from the peripheral vein in every patient on the first day after admission.Serum vascular endothelial growth factor was determined with ELISA,while nitric oxide determined with nitrate reductase.Results Serum vascular endothelial growth factor levels in group A and B were much higher than that in group C(P<0.01).Serum vascular endothelial growth factor levels in group B were much higher than that in group A(P<0.01).Serum nitric oxide levels in group A and B were lower than that in group C(P<0.01);Serum nitric oxide levels in group B were much higher than that in group A(P<0.01).Conclusion It is suggested that the disequilibrium of serum vascular endothelial growth factor and nitric oxide may contribute to the occurrence and development of coronary heart disease.