慢性阻塞性肺疾病4例单肺移植(英文)

回顾性分析4例慢性阻塞性肺病单肺移植患者的临床资料,均接受尸体供肺移植,双肺弥漫性肺气肿1例接受右肺移植;弥漫性肺气肿并部分相互融合成肺大疱3例接受左肺移植,此3例分别于移植术中(1例)和移植后(2例)接受右肺减容术。移植后采用他克莫司、霉酚酸酯及泼尼松预防排斥反应,同时给予达利珠单抗或抗胸腺细胞球蛋白进行诱导治疗。4例移植手术经过顺利,1例移植后第5天发生急性排斥反应,经甲泼尼龙冲击治疗逆转。2例受者顺利出院,1例存活已超过2年;2例分别于肺移植后第74,77天死亡。

Allogenic single-lung transplantation for chronic obstructive pulmonary disease in 4 cases

Clinical data of 4 patients with chronic obstructive pulmonary disease who underwent allogenic single-lung transplantation were retrospectively analyzed. All cases received corpse donor lungs. One case with diffuse emphysema underwent right lung transplantation. and 3 received left lung transplantation. including one underwent fight lung volume reduction during surgery and 2 cases underwent right lung volume reduction post-transplantation. The inductive treatment with daclizumab or antithymocyte globulin was done and the rejection was prevented with Tacrolimus. mycophenolate and prednisone. The surgery was successfulin 4 cases. One case developed acute rejection on the fifth day post-transplantation. and controlled using methylprednisolone. Two cases discharged successfully, of whom one lived more than 2 years. Two cases died 74 days and 77 days after lung transplantation. respectively.