| 高效液相色谱法测定维C银翘胶囊中马来酸氯苯那敏的含量 |
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| 引用本文： | 沈素梅,唐秀玲,周梁. 高效液相色谱法测定维C银翘胶囊中马来酸氯苯那敏的含量[J]. 临床合理用药杂志, 2013, 6(20): 30-31 |
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| 作者姓名： | 沈素梅 唐秀玲 周梁 |
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| 作者单位： | 沈素梅 (广西柳州市中医院,545001)； 唐秀玲 (广西壮族自治区食品药品检验所,南宁市,530021)； 周梁 (广西中医药大学,南宁市,530001)； |
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| 摘 要： | 目的建立维C银翘胶囊中马来酸氯苯那敏含量测定的高效液相色谱法（HPLC）。方法采用HPLC以乙腈—0.3%十二烷基硫酸钠溶液—磷酸（60∶40∶0.02）（三乙胺调pH至3.3）为流动相,在检测波长262nm处测定马来酸氯苯那敏含量。结果马来酸氯苯那敏在0.2046～0.8182μg范围内具有良好的线性关系,相关系数r=1.0000,平均加样回收率为101.57%（RSD=0.70%）。结论该方法简便、可靠,重现性好,可用于维C银翘胶囊的质量控制。
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| 关 键 词： | 维C银翘胶囊 马来酸氯苯那敏 高效液相色谱法 |
Determination of chlorphenamine maleate in Vitamin C Yinqiao Capsule by HPLC |
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| SHEN Su-mei,TANG Xiu-ling,Zhou Liang. Determination of chlorphenamine maleate in Vitamin C Yinqiao Capsule by HPLC[J]. Chinese Journal of Clinical Rational Drug Use, 2013, 6(20): 30-31 |
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| Authors: | SHEN Su-mei TANG Xiu-ling Zhou Liang |
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| Affiliation: | . (Liuzhou City Hospital of Traditional Chinese Medicine,Liuzhou,Guangxi 545001,China ) |
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| Abstract: | Objective To develop a method for determination of chlorphenamine maleate in Vitamin C Yinqiao Capsule with high performance liquid chromatography （ HPLC） . Methods The chlorphenamine maleate in the capsule were determined by HPLC with a mobile phase of acetonitrile-twelve alkyl sodium sulfate-phosphoric acid（ three ethylamine adjusted to pH3. 3） （ 60∶40∶0. 02） . The detection wavelength was set at 262nm. Results The linear range of chlorphenamine maleate was in the ranges of 0. 2046 ～ 0. 8182μg（ r = 1） . The average recovery was 101. 57% （ RSD of 0. 70% ） . Conclusion The method is simple,rapid and reproducible,it can be used for the quality control of Vitamin C Yinqiao Capsule. |
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| Keywords: | Vitamin C Yinqiao Capsule Chlorphenamine maleate HPLC |
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