A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment |
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| Authors: | B Fornstedt A Carlsson |
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| Institution: | (1) Present address: Department of Pharmacology, University of Göteborg, Göteborg, Sweden |
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| Abstract: | Summary Reserpine administration (5 mg/kg, i.p.) to guinea pigs resulted in marked and long lasting dopamine (DA) depletion and a rapid, short lasting, increase of 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. A marked and sustained increase of the level of 5-S-cysteinyl-dopamine, which is an adduct presumably formed following autoxidation of DA, started 3–4 h following the DA and DOPAC changes. Only small changes in the levels of the 5-S-cysteinyl adducts of DOPAC and 3,4-dihydroxyphenylalanine (DOPA) were found. |
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| Keywords: | Catechol-autoxidation 5-S-cysteinyl-dopamine 5-S-cysteinyl-DOPA 5-S-cysteinyl-DOPAC reserpine |
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