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Lymphocyte subpopulations in the blood and cerebrospinal fluid of multiple sclerosis patients in active disease
Authors:Daniel Rukavina,Juraj Sep&#  i&#  ,Miljenko Dori&#  ,Petar Ledi&#  ,Luka Zaputovi&#  ,Predrag Eberhardt
Affiliation:Department of Physiology and Immunology and Clinic of Neurology, Faculty of Medicine, University of Rijeka, Rijeka, Yugoslavia
Abstract:Lymphocyte subpopulations (total T cells, active T cells and B cells) were simultaneously analyzed in peripheral blood and CSF of MS patients. All patients were in active disease, 3 to 4 weeks after first signs of disease activation appeared. Per cent levels and absolute numbers of examined lymphocyte subpopulations in the blood of MS patients were significantly lower than in healthy controls. In MS, the level of active T lymphocytes was lower in CSF than in peripheral blood. The results support our earlier observations relating to the role of active T lymphocytes in the clinical course of disease.
Keywords:Active T cells    blood and CSF    multiple sclerosis    T and B lymphocytes
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