红霉素的剂型与生物有效度研究

<正> 作为全身应用的栓剂其药物通过直肠粘膜吸收大约有50—75%是直接进入大循环的而不通过人体的解毒机构——肝脏。因而可减少或消除药物对胃肠道的刺激作用和其他付作用,特别是适用于在胃和小肠中遭到破坏的药物。另外,栓剂与口服剂型比较有吸收完全,

INVESTIGATED ON THE VARIOUS DOSAGE FORMS AND THEIR BIOAVAILABILITY OF ERYTHROMYCIN

Various dosage forms and their bioavailability of Erythromycin is investi- gated in this paper. Peak blood leve was reachet soon after the injection of Erythromycin,but a rapid straightline fall ensued.The tablet meeted the official demands both in the contents and in disintegration limit,but the enteric-coated preparation was bioinequavalent. Three kinds of China-made bases were used to make the suppository:Oleum Linderae,Semisynthetic Coconut Oil and Semisynthetic Fatty Acid Esters.All the three preparations showeda higher blood level in rabbits than that made from Cocoa butter,the semisynthetic-fatty-acid-esters preparation being about three times that of the latter.Peak blood level appeared 30 min.after the adminis- tration of the suppository and an adequate blood level could be maintained for a certain period of time thereafter.Considering all this its wide application is recommended.