颅脑损伤病人垂体前叶激素和甲状腺素变化的意义

目的：研究颅脑损伤病人垂体前叶激素，甲状腺激素与伤情严重程度及预后的关系。方法：采用时间分辨荧光免疫法检测97例急性颅脑损伤得血清泌乳素（PRL）、促卵泡生成素（FSH）、促甲状腺激素（TSH）、甲状腺素（TT3、TT4、FT3、FT4）水平，60例正常人作对照，伤情及预后分别采用GCS和GOS评分评估，对激素水平的变化与伤情严重程度及预后的关系进行分析。结果：颅脑损伤急性期PRL、FSH显增高，TT3、FT3显降低，损伤越严重，上述指标变化越明显，预后越差，上述指标变化亦越明显，结论：颅脑损伤病人PRL，FSH、TT3、FT3水平的变化可用来判断伤情的严重程度，观察预后。

Meanings of Changes in Anterior Pituitary Hormones and Thyroxine in Patients with Craniocerebral Injury

Objective To explore the correlation of changes in the anterior pituitary hormones and thyroxine with the severity and prognosis in patients with craniocerebral injury.Methods The changes in serum prolactin(PRL),follicle stimulating hormone(FSH),thyroid stimulating hormone(TSH)and thyroxine(TT 3 ,TT 4,FT 3 ,FT 4 )were determined by time-resolved fluoroimmunoassay in97patients with craniocerebral injury,and were compared with that in60normal persons serving as control group.The severity of the injury and the prognosis were assessed respectively by GCS and GOS.The relationship between the changes in the hormones and the severity of the illness or the prognosis was analyzed.Results In the acute phase of craniocerebral injury,the serum PRL and FSH were significantly increased,and TT 3 and FT 3 were greatly decreased.The severer brain injury was,the more obviously the hormones changed;the worse prognosis was,the more obviously they changed,too.Conclusion The changes in PRL,FSH,TT 3 ,FT 3 in the acute phase of the craniocerebral injury can be used to estimate the severity and the prognosis in the patients with craniocerebral injury.