Cimetidine increases the pancreatic response to histamine |
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| Authors: | J. A. Pariente L. P. Francis G. M. Salido J. A. Madrid |
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| Affiliation: | (1) Department of Physiology, Faculty of Veterinary Sc., University of Extremadura, 10071 Cáceres, Spain |
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| Abstract: | The effects of histamine alone and histamine plus cimetidine on basal pancreatic exocrine secretion were determined in anaesthetized rabbits with an acute pancreatic cannula. Intravenous histamine administration (0.2–0.8n mol/kg/min) increased pancreatic enzyme secretion. A much greater stimulative effect on pancreatic (cimetidine 4  mol/kg/min). The results indicate that in the rabbit pancreas the stimulatory effect of histamine is mediated by H1 receptors. |
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