| 白藜芦醇对脓毒症大鼠急性肺损伤的保护作用及对HMGBl及TLR4mRNA表达的影响 |
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| 引用本文： | 周继红,韦晓谋,兰慧慧,郑妮,李金万,陈宏. 白藜芦醇对脓毒症大鼠急性肺损伤的保护作用及对HMGBl及TLR4mRNA表达的影响[J]. 中药药理与临床, 2015, 0(2): 138-139 |
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| 作者姓名： | 周继红 韦晓谋 兰慧慧 郑妮 李金万 陈宏 |
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| 作者单位： | 柳州市工人医院 |
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| 摘 要： | 目的:研究白藜芦醇(Resveratrol,Res)对脓毒症大鼠急性肺损伤(Acute lung injury,ALI)的保护作用及对ALI大鼠肺组织中高迁移率族蛋白(high mobility group box 1 protein,HMGBl)及Toll样受体4(Toll-like receptor 4,TLR4)mRNA表达的影响。方法:将大鼠随机分为假手术组(Sham组)、脓毒症组(Sep组)和白藜芦醇组(Res组),采用盲肠结扎穿刺术(Cecal ligation and puncture,CLP)制备脓毒症相关性ALI大鼠模型,造模1 h后,Res组给予40mg/kg,Sham和Sep组给予等量生理盐水,均经股静脉注射。各组分别于2、6、12和24h,取大鼠肺组织,HE染色观察病理形态学变化,RT-PCR检测脓毒症大鼠各器官组织HMGB1及TLR4的mRNA的动态表达变化。结果:Res组在造模后12 h,肺组织病理变化与Sep组相比有所减轻,24 h Res作用达到最强,各种病理改变明显减轻,部分肺组织开始接近正常形态;Res组与Sepsis组比较,肺组织HGMB1及TLR4 mRNA表达明显下调。结论:Res可以通过下调肺组织HGMB1及TLR4 mRNA表达减轻脓毒症诱导的肺损伤。
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| 关 键 词： | 白藜芦醇 脓毒症 急性肺损伤(ALI) 高迁移率族蛋白1(HMGB1),Toll样受体4(TLR4) |
Protective effect of resveratrol on rats with acute lung injury induced by sepsis in rat and its influence on mRNA expressionsof high mobility group box 1 protein and Toll-like receptor 4 |
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| Zhou Jihong;Wei Xiaomou;Chen Hong. Protective effect of resveratrol on rats with acute lung injury induced by sepsis in rat and its influence on mRNA expressionsof high mobility group box 1 protein and Toll-like receptor 4[J]. Pharmacology and Clinics of Chinese Materia Medica, 2015, 0(2): 138-139 |
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| Authors: | Zhou Jihong Wei Xiaomou Chen Hong |
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| Affiliation: | Zhou Jihong;Wei Xiaomou;Chen Hong;Lan Huihui;Zheng Ni;Li Jinwan;Intensive Care Unit,The Fouth Affiliated Hospital,Guangxi Medical University; |
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