| 血脂吸附剂的合成及吸附性能研究 |
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| 引用本文： | 莫建坤 邱玉超 韦莉萍 谢少玉 兰萌 雷达 徐耿明. 血脂吸附剂的合成及吸附性能研究[J]. 第一军医大学学报, 2005, 25(9): 1161-1163 |
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| 作者姓名： | 莫建坤 邱玉超 韦莉萍 谢少玉 兰萌 雷达 徐耿明 |
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| 作者单位： | [1]广东省第二人民医院检验科,广东广州510317 [2]南方医科大学南校区,广东广州510315 [3]南方医科大学珠江医院,广东广州510311 |
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| 基金项目： | 广州市科技攻关课题资助项目（200423-E0171）,致谢：感谢华南农业大学理学院卢其明教授给予的指导. |
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| 摘 要： | 目的合成纳米复合材料作为吸附剂，并检测其吸附效果。方法制备聚乙二醇（PEG）／蒙脱石（MMT）纳米复合材料．采用X-射线衍射分析PEG／MMT插层复合物的结构；应用合成的纳米复合材料做血脂和血清蛋白吸附实验。结果较大相对分子质量的PEG与MMT插层后的层间距更大。PEG／MMT纳米复合材料对血清中的甘油三脂、总胆固醇、低密度脂蛋白胆固醇吸附性强，对血清中白蛋白的吸附性能相对较弱，而MMT吸附性能差。结论PEG／MMT纳米复合材料可以进一步开发为血脂吸附材料。
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| 关 键 词： | 纳米技术 吸附剂 蒙脱石 聚乙二醇 血脂 白蛋白 |
| 文章编号： | 1000-2588（2005）09-1160-03 |
| 收稿时间： | 2005-03-05 |
Blood lipid adsorption of polyethylene glycol/montmorillonite nanocomposite |
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| Mo JianKun;Qiu YuChao;Wei LiPing;Xie ShaoYu;Lan Meng;Lei Da;Xu GengMing. Blood lipid adsorption of polyethylene glycol/montmorillonite nanocomposite[J]. Journal of First Military Medical University, 2005, 25(9): 1161-1163 |
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| Authors: | Mo JianKun Qiu YuChao Wei LiPing Xie ShaoYu Lan Meng Lei Da Xu GengMing |
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| Affiliation: | Second People's Hospital of Guangdong Province, Guangzhou 510315, China. |
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| Abstract: | OBJECTIVE: To evaluate the effect of polyethylene glycol/montmorillonite (PEG/MMT) nanocomposite material in adsorption of triglyceride (TG), cholesterin and low-density lipoprotein-cholesterol (LDL-C). METHODS: The structure of PEG/MMT nanocomposite was analyzed by means of X ray diffraction and its effect of blood lipid and albumin adsorption was evaluated in comparison with Na-MMT. RESULTS: The interval distance was larger when the PEG of greater molecular weight was used for preparing the nanocomposite, and PEG/MMT nanocomposite had greater adsorption rate of TG, cholesterin and LDL-C in serum than that of serum albumin. MMT material had poor adsorption effect. CONCLUSION: PEG/MMT nanocomposite possesses the potential as a novel adsorbent of blood lipid for clinical use. |
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| Keywords: | nanotechnology adsorbent materials montmorillonite polyethylene glycol, lipid profile albumin |
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