创伤患者血清免疫球蛋白、补体和C-反应蛋白的变化

目的：探讨创伤患者免疫功能的变化及临床意义。方法：３０例创伤术后患者分为创伤组及创伤并发症组，分别在术后第１，７及１４日测定外周血清免疫球蛋白ＩｇＧ，ＩｇＡ，ＩｇＭ，补体Ｃ３，Ｃ４及Ｃ－反应蛋白（ＣＲＰ），并与正常对照组进行对比分析。结果：创伤组及创伤并发症组的免疫球蛋白，补体均在术后第１日明显降低，而ＣＲＰ明显升高。

Changes in serum immunoglobulins, complements and C-reactive protein in trauma patients

Objective:To investigate the clinical significance of changes in immune functions in trauma patients.Methods:30 trauma patients were divided into trauma group and trauma complication group.Serum concentrations of IgG,IgA,IgM,complement 3 (C 3),complement 4 (C 4) and Creactive protein (CRP) were determined on days 1,7 and 14 after operation and the results were compared with normal control group.Results:IgG,IgA,IgM,C 3 and C 4 decreased whereas CRP markedly increased in both trauma group and trauma complication group on day 1 after operation (all P <0 05).IgG,IgA,IgM,C 3 and C 4 returned to normal range and CRP tended to approach normal values in trauma group on day 7 after operation (all P >0 05).However,IgG,IgA,C 3 and C 4 were still significantly low whereas CRP was even much higher in trauma complication group on day 7 after operation(all P <0 01),IgG,IgA,IgM,C 3 and C 4 were markedly increased in trauma group (all P <0 01) while IgG,IgA,IgM and C 4 were slightly higher in trauma complication group on day 14 after operation.Conclusions:These data suggest that humoral immune function was suppressed during early phase after trauma.The kinetic changes in IgG,IgA,IgM,C 3,C 4 and CRP might be used as parameters to evaluate the general state of trauma patients.