Pregnancy-associated plasma protein A: circulating levels during normal pregnancy |
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| Authors: | J Folkersen J G Grudzinskas P Hindersson B Teisner J G Westergaard |
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| Affiliation: | 1. Institute of Medical Microbiology, Odense University Odense, Denmark;2. Department of Obstetrics and Gynaecology, Odense University Hospital Odense, Denmark;3. Department of Obstetrics and Gynaecology, University of Sydney and Royal North Shore Hospital of Sydney Sydney, Australia |
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| Abstract: | The development of specific and sensitive electroimmunoassays for a recently identified high molecular weight alpha-2 mobile pregnancy-specific protein (pregnancy-associated plasma protein A, PAPP-A or SP4) is described. These assays have permitted the detection of circulating levels of PAPP-A (10 microgram/L) as early as the fifth week of pregnancy. In all 18 subjects studied, the levels of PAPP-A rose from first detection in the first trimester until delivery at term. The development of these assays now permit the evaluation of PAPP-A measurement as a diagnostic test of early pregnancy and as an index of fetal well-being throughout gestation. |
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| Keywords: | Reprint requests: J. Folkersen Institut for Medicinsk Mikrobiologi J. B. Winslows Vej 19 DK-5000 Odense Denmark. |
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