针刺治疗小儿麻痹后遗症血中胆碱酯酶活力变化的研究

<正> 乙酰胆碱(Ach)是一种具有神经生理活性的物质。众所周知,Ach 是许多外周神经的神经递质。关于 Ach 及其合成和分解的酶的代谢,受到众多的关注。它们的改变与神经系统的多种疾病有关(如神经——肌肉疾病、癫痫、脑外伤及脑炎等)。据报道,肌强直病人的肌组织中 Ach 的含量增高(正常肌肉中含量很少),同时胆碱酯酶(ChE)活性比正常人低;癫痫发作时,脑脊液和血液中都能见有 Ach 的含量增多。曾有人发现癫痫患者脑 Ach 较正常人增加250%,而ChE 增加35%。小儿麻痹后遗症是因神经因素引起的肌肉萎缩疾病,其体内胆碱能系统活动情况如何呢?为此我们对针刺治疗小儿麻痹后遗症病人血中胆碱酯酶的活力变化进进了观察,结果如下。

STUDIES ON CHANGES OF CHOLINESTERASE ACTITIES IN BLOOD UNDER ACUPUNCTURE TREATMENT FOR SEQUELAE OF POLIOMYELITIS

By spectrophotometry we observed the changes of ChE activities in bloodof 16 cases sequelitis of poliomyelitis after acupuncture treatment.(1)Before acupuncture the ChE actiuities in the plasma of 16 cases wereslightly higher than the normal level.(2)After acupuncture treatment the ChE activities of the patients weremarked decreased than before(P<0.01).(3)These patients were divided into two groups:acupuncture and electro-acuputicture.Among them the ChE activites of electro-acupuncture groupwere statically sigificant after treatment than before(P<0.05).It is suggested that after acupuncture,especially electro-acupuncture,thedecrease of ChE activities lead up to the increase of Acetyl choline at theneuro-muscular junction.So transmissive function of Ach in the bodies wasincreased.And finally,the patients' myatrophies were improved.Morestudies are needed to confirm the mechanism of acupuncture treatment forsequelae of poliomyelitis.