Ontogenic changes of kynurenine aminotransferase I activity and its expression in the chicken retina |
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Authors: | Rejdak Robert Zielinska Elzbieta Shenk Yana Turski Waldemar A Okuno Etsuo Zarnowski Tomasz Zagorski Zbigniew Zrenner Eberhart Kohler Konrad |
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Affiliation: | Department of Pathophysiology of Vision and Neuro-Ophthalmology, Division of Experimental Ophthalmology, University Eye Hospital, R?ntgenweg 11, D-72076 Tübingen, Germany. rrejdak@yahoo.com |
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Abstract: | Kynurenine aminotransferases are key enzymes for the synthesis of kynurenic acid (KYNA), an endogenous glutamate receptor antagonist. The study described here examined ontogenic changes of kynurenine aminotransferase I (KAT I) activity and its expression in the chicken retina. KAT I activity measured on embryonic day 16 (E16) was significantly higher than at all other stages (E12, P0 and P7). Double labeling with antibodies against glutamine synthetase showed that on P7 KAT I was expressed in Müller cell endfeet and their processes in the inner retina. Since KAT I activity is high in the late embryonic stages, it is conceivable that it plays a neuromodulatory role in the retina during the late phase of embryogenesis. |
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Keywords: | Kynurenine aminotransferase I Kynurenic acid Müller cell Retinal development |
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