甘氨酸亚铁对大鼠缺铁性贫血模型的影响

[目的]以Fe^2＋作为中心金属离子，合成一种氨基酸配合物-甘氨酸亚铁（FeGly2），并对其补血作用进行研究。[方法]用甘氨酸和Fe^2＋合成螯合铁，同时用红外光谱和原子吸收光谱对甘氨酸亚铁结构进行测定；并用大鼠贫血模型，观察甘氨酸亚铁补血作用。[结果]缺铁性贫血大鼠灌胃给予200mg／kg FeGly2和300mg／kg FeSO4制剂后，血液中血红蛋白（Hb）明显增加（P〈0.01），而且200mg／kg FeGly2和300mg／kg FeSO4制剂的升高血红蛋白含量的作用相当。[结论]甘氨酸亚铁具有改善大鼠缺铁性贫血的作用。

The Effect of Ferrous Glycine Sulfate in Rat Iron-deficiency Anemia Model

[Objective] To synthesize an amino acid coordinately compounds-Ferrous Glycine Sulfate(FeGly2) using Fe2+ as central iron and study the effect of blood enrichment.[Method]To synthesize the chelate iron using glycin and Fe2+ and measure the constructor of Ferrous Glycine Sulfate by IR spectrum and atomic absorption spectroscopy.To observe the blood enrichment effect of FeGly2 by rat anemia model.[Result] After separately treatment with 200 mg/kg FeGly2 and 300 mg/kg FeSO4 by intragastric administration,the h...