阻塞性睡眠呼吸暂停低通气综合征患者肺功能的变化

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者肺功能的变化。方法对经多导睡眠图监测（PSG）确诊的142例OSAHS患者（OSAHS组）及52例体检健康者（对照组），分别行肺通气功能检测指标包括潮气量（VT）、每分通气量（MV）、最大肺活量（VCMAX）、补呼气量（ERV）、用力肺活量（FVC）、1秒用力呼气容积（FEV1）、1秒率（FEV1／FVC）、最大分钟通气量（MVV）、用力呼气峰流量（PEF）和75％用力呼气容积流量（FEF75）、50％用力呼气容积流量（FEF50）、25％用力呼气容积流量（FEF25）]测定及比较，并作呼吸暂停低通气指数（AHI）及体重指数（BMI）与上述指标的相关性分析。结果OSAHS组患者肺通气功能指标ERV、VCMAX、FVC、FEV1、FEF50、MV、MVV均较对照组显著下降（均P〈0．01）。OSAHS组患者AHI与MV、ERV、VCMAX、FVC、MVV呈负相关（r=-0.321～-0．244，均P〈0．01）；BMI与ERV、VCMAX、FVC、MVV、MV呈负相关（r==-0．375～-0205，P〈005或0．01）。与FEV1／FVC呈正相关（r=0．385，P〈001）。结论OSAHS患者存在肺功能损害，损害程度与BMI及AHI有关，需要引起重视。

The changes of pulmonary function in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the changes of pulmonary function in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods A total of 142 OSAHS patients which were confirmed by polysomonograph（PSG） and 52 healthy volunteers were enrolled in the study. All the subjects received pulmonary function tests, including tidal volume （ VT ）,minute ventilation （MV）, maximum vital capacity（VCMAX ）, expiratory reserve volume （ERV）, forced vital capacity（ FVC）,forced expiratory volume in one second （FEV1）, FEVl/FVC,maximum minute ventilation volume （MVV）, peak expiratory flow （PEF）,75% forced expiratory volume flow（ FEF75 ）,50% forced expiratory volume flow（ FEF50 ）,25% forced expiratory volume flow（ FEF25 ）. The correlation of above pulmonary function indicators with apnea-hypopnea index （AHI）, body mass index （BMI） was analyzed. Results The values of ERV, VCMAX, FVC, FEV1, FEF50, MV, MVV in OSAHS patients were lower than those in healthy volunteers （P〈0.01）. AHI was negatively correlated with MV, ERV,VCMAX, FVC, MVV （r=-0.321 - -0.244, P〈0.01）; BMI was negatively correlated with ERV, VCMAX, FVC, MVV,MV （r=-0.375 - -0.205, P〈0.05 or P〈0.01）,and BMI was positively correlated with FEV1/FVC （r=0.385, P〈0.01）. Conclusion The pulmonary functions of OSAHS patients are impaired, which are closely correlated with AHI and BMI of the patients.