芪月降脂片对高脂血症大鼠血脂代谢的影响

目的：观察芪月降脂片（QHT）对高脂血症大鼠血脂代谢的影响。 方法：Wistar大鼠随机分为正常对照组、高脂模型组、阳性对照组及QHT 1.75、3.50、7.00 g·kg^-1组。采用喂饲高脂饲料同时灌胃QHT，连续4周，观察QHT对大鼠高脂血症的预防作用；采用喂饲高脂饲料1周后灌胃QHT，连续3周，观察QHT对大鼠高脂血症的治疗作用。 结果：与高脂模型组比较，QHT预防和治疗方式给药均能明显降低实验性高血脂大鼠血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）含量、动脉硬化指数（AI）、TC/HDL-C及LDL-C/HDL-C比值（P<0.05或P<0.001），治疗给药亦能明显提高实验性高脂血症大鼠血清高密度脂蛋白胆固醇（HDL-C）含量（P<0.05）。 结论：QHT对大鼠实验性高脂血症具有预防和治疗作用。

Effects of Qiyue hypolipidemic tablets on blood lipid metabolism in hyperlipidemia rats

Objective To study the effects of Qiyue hypolipidemic tablets (QHT) on blood lipid metabolism in hyperlipidemia rats. Methods Wistar rats were divided into 6 groups at random: normal contrast group, hyperlipidemic model group, positive contrast group and QHT 7.0, 3.5, 1.75 g·kg~-1 groups. These rats were continuously fed for four weeks. So the preventive effects of QHT on experimental hyperlipidemic rats could be observed. After the rats were fed with high-fat feed for one week, they were treated with 7.0,3.5, and 1.75 g·kg~-1 doses of QHT for three weeks. The therapeutical effects of QHT on experimental hyperlipidemia in rats were observed. Results Every dose of QHT could decrease the serum TG, TC, LDL-C , TC/HDL-C and LDL-C/HDL-C and AI in hyperlipidemic rats. And the theraputical dose of QHT increased the serum HDL-C in experimental hyperlipidemic rat model. Conclusion QHT have preventive and therapeutical effects in experimental hyperlipidemia rats.