STK15 F31I polymorphism is associated with breast cancer risk: a meta-analysis involving 25,014 subjects |
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Authors: | Li-Xin Qiu Bo Chen Chen Mao Ping Zhan Hui Yuan Kai Xue Jin Li Xi-Chun Hu |
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Affiliation: | (1) Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China;(2) Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;(3) Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China;(4) Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China;(5) Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China;(6) Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, China; |
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Abstract: | Published data on the association between STK15 F31I polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, Web of Science, and Chinese Biomedicine Database were searched. Crude ORs with 95% CIs were used to assess the strength of association between the STK15 F31I polymorphism and breast cancer risk. The pooled ORs were performed for codominant model (FI vs. FF; II vs. FF), dominant model (FI + II vs. FF), and recessive model (II vs. FI + FF), respectively. A total of 10 studies including 10,537 cases and 14,477 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with II variant genotype in homozygote comparison and recessive genetic model when all studies were pooled into the meta-analysis (for II vs. FF: OR = 1.23, 95% CI = 1.10–1.37; for recessive model: OR = 1.21, 95% CI = 1.05–1.40). In the subgroup analysis by ethnicity, significantly increased risks were found for II allele carriers among Caucasians (for II vs. FF: OR = 1.24, 95% CI = 1.08–1.43; for recessive model: OR = 1.21, 95% CI = 1.00–1.45); significantly increased risks were also found among Asians for II versus FF (OR = 1.21; 95% CI = 1.01–1.45). In conclusion, this meta-analysis suggests that the STK15 31II allele is a low-penetrant risk factor for developing breast cancer. |
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