阿魏洛芬的解热和局麻作用

肌注阿魏洛芬45mg和200mg/kg对伤寒、副伤寒三联菌苗和酵母粉悬液引起家兔和大鼠的发热反应具有明显的解热作用,其强度分别与肌注阿斯匹林35mg和100mg/kg基本相当。1%阿魏洛芬局部用药除对家兔角膜反射无影响外,在蟾蜍离体坐骨神经动作电位和豚鼠皮内丘疹痛觉反应中其阻滞强度明显弱于同浓度普鲁卡因和利多卡因,但均显示有一定的可逆性局麻效应。上述作用与前文结果进一步说明阿魏洛芬可能成为抗炎解热镇痛新药。

ANTIPYRETIC AND ANESTHETIC ACTIVITY OF FERULOFEN

Ferulof en ( FL, 45mg and 200mg/kg im ) showed marked antipyretic effect on rabbit fever induced by typho-paratyhoid vaccine and on rat fever induced by yeast powder suspension respectively. Their potency and action phase were similar to those of aspirin ( 35mg and 100mg/kg) . Furthermore, it blocked the action potential of sciatic nerve in toad to some extent and had a certain local anesthetic effect on guinea pigs in intradermic wheal test, but much weaker than procaine and lidocaine at the same concentration. It had no obvious influence on corneal reflex in rabbits.It can be concluded from these findings that together with the results of previous paper the findings of this paper further indicated FL may be proved to be a new antiinflammatory, antipyretic and analgesic drug.