3H-imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium |
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| Authors: | Per Plenge E. T. Mellerup |
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| Affiliation: | (1) Psychochemistry Institute, University of Copenhagen, Rigshospitalet, 9, Blegdamsvej, DK-2100 Copenhagen Ø, Denmark |
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| Abstract: | The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation. |
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| Keywords: | 3H-imipramine binding site Imipramine Lithium Rat |
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