| 拳参乙醇提取物的免疫调节作用 |
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| 引用本文： | 李珂珂,栾希英. 拳参乙醇提取物的免疫调节作用[J]. 中国现代应用药学, 2011, 28(1): 21-25 |
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| 作者姓名： | 李珂珂 栾希英 |
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| 作者单位： | 滨州医学院药学院，山东 烟台 264003;滨州医学院基础学院，山东 烟台 264003 |
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| 基金项目： | 滨州医学院科技计划项目(BY2007KJ09) |
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| 摘 要： | 目的 研究拳参乙醇提取物(BRE)的免疫调节作用.方法 在小鼠体外实验中,通过比色分析法检测小鼠巨噬细胞系RAW264.7细胞吞噬中性红的能力.在小鼠体内实验中,通过测定胸腺、脾脏重量并计算脏器指数;MTT法检测T淋巴细胞增殖和NK细胞活性;鸡红细胞免疫后测定小鼠血清溶血素抗体水平;ELISA法测定血清中IL-2含量....
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| 关 键 词： | 拳参 乙醇提取物 免疫调节 |
| 收稿时间： | 2010-02-26 |
Immunoregulatory Function of Bistortae Rhizoma Ethanol Extract |
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| LI Keke and LUAN Xiying. Immunoregulatory Function of Bistortae Rhizoma Ethanol Extract[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(1): 21-25 |
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| Authors: | LI Keke and LUAN Xiying |
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| Affiliation: | Binzhou Medical University, College of Pharmacy, Yantai 264003, China;Binzhou Medical University, College of Basic Sciences, Yantai 264003, China |
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| Abstract: | OBJECTIVE To study immunoregulatory function of Bistortae Rhizoma ethanol extract (BRE). METHODS The percentage of phagocytosis of neutral red by RAW264.7 cell line from mouse macrophages was detected by colorimetric assay, . normal mice, weigh the immunological organs, MTT method was employed to investigate T lymphocyte transformation efficiency and the cytotoxicity of NK cells; measurement of the level of serum hemolysin antibody in mice immunized by chicken red blood cells and the content of IL-2 in serum with ELISA. RESULTS BRE can improve phagocytosing function of RAW264.7 macrophage cell line, increase spleen index and thymus index, promote proliferation of T lymphocyte, increase the cytotoxicity of NK cells, raise the level of serum hemolysin antibody and the content of IL-2 in normal mice. CONCLUSION BRE possesses a potential immunoregulatory function. |
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| Keywords: | Bistortae Rhizoma ethanol extract immunoregulatory |
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